KYIV, Jan 23 - Russian missiles struck three Ukrainian cities Tuesday, including its two biggest, killing at least seven people and wrecking apartment buildings after Moscow shunned any deal backed by Kyiv and its Western allies to end the nearly 2-year-old war.

The barrage included more than 40 ballistic, cruise, anti-aircraft and guided missiles, officials reported, in what the United Nations said appeared to be the heaviest bombardment since early January, when hundreds of Ukrainian civilians were killed, The Associated Press reported. Ukraine’s air force, whose defenses include Western-supplied systems, said it intercepted 21 of the missiles.

The attacks keep Ukrainians on edge while the 1,500-kilometer (930-mile) front line has barely budged. Both sides’ inability to deliver major gains on the battlefield has pushed the fighting toward trench and artillery warfare. Analysts say Russia stockpiled missiles at the end of last year to press a winter campaign of aerial bombardment.

The recent Russian bombardment was “an alarming reversal” of a trend last year that saw a drop in civilian casualties from Kremlin attacks, the U.N. said.

More than 10,000 civilians have been killed and nearly 20,000 injured since Russia’s full-scale invasion in February 2022, the U.N. said.

Tuesday’s onslaught in Kharkiv, in northeastern Ukraine, killed six people and injured 57, including eight children, the U.N. said. The missiles damaged about 30 residential buildings and shattered hundreds of windows in icy weather, regional Gov. Oleh Syniehubov said.

Russia used S-300, Kh-32 and hypersonic Iskander missiles in the attack, he said.

A five-story apartment building appeared to have been directly hit by several missiles around dawn, the U.N. Human Rights Mission in Ukraine said in a statement.

An unknown number of people were trapped in the rubble with the temperature falling to minus 7 degrees Celsius (19 degrees Fahrenheit), said Kharkiv Mayor Ihor Terekhov.

Kharkiv, about 30 kilometers (18 miles) from the border, has often felt the brunt of Russia’s winter campaign of long-range strikes that commonly hit civilian areas.

Four districts of Kyiv came under an attack that injured at least 20 people, including a 13-year-old boy, according to Mayor Vitalii Klitschko. Officials corrected initial reports that a civilian had been killed in the capital, saying the wounded person was hospitalized on life support.

U.N. staff visited a Kyiv neighborhood with a damaged residential building, a school, a sports center and a kindergarten.

A missile also killed a 43-year-old woman and damaged two schools and eight high-rise buildings in Pavlohrad, an industrial city in the eastern Dnipro region, the country’s presidential office said.

In Balakliia, in the Kharkiv region, an 88-year-old man and a 78-year-old woman were rescued from the rubble of a house after Russian shelling, it said.

In the south, Russia attacked the city of Beryslav with drones, killing a 69-year-old man on a motorcycle. (ap/ez)