KYIV, Jan 2 - Ukraine’s two largest cities came under attack early Tuesday from Russian missiles that killed five people and injured as many as 130, officials said, as the war approached its two-year mark and the Kremlin stepped up its winter bombardment of urban areas.

Air defenses shot down all 10 of the Russian Kinzhal missiles, which can fly at 10 times the speed of sound, out of about 100 of various types that were launched, said Gen. Valerii Zaluzhnyi, Ukraine’s commander-in-chief, The Associated Press reported.

But other missiles got through in Kyiv and in Kharkiv, the provincial capital of the northeastern region. In Kyiv and its surrounding region, four people were killed and about 70 were wounded, while in the Kharkiv region, one person was killed and about 60 were hurt, the Interior Ministry said.

The Kh-47M2 Kinzhal is an air-launched ballistic missile that is rarely used by Russian forces due to its cost and limited stocks. The barrage fired Tuesday was the highest number used in one attack since the start of the war, Ukraine air force spokesperson Yurii Ihnat said.

The latest round of attacks by Russia began Friday with its largest single assault on Ukraine of the war, as fighting along the 1,000-kilometer (620-mile) front line has subsided into grinding attrition amid winter. At least 41 civilians were killed since the weekend.

At a nine-story Kyiv apartment building where two people were killed, 48-year-old Inna Luhina was getting ready for work when a blast shattered her windows and she and other family members, including her 80-year-old mother, were struck by flying glass.

Russia fired almost 100 missiles of various types in the attacks, President Volodymyr Zelenskyy said on X, formerly Twitter. He claimed at least 70 were shot down, almost all of them in the Kyiv area, noting that Western-supplied air defense systems such as Patriots and NASAMS had saved hundreds of lives.

In his nightly address, Zelenskyy said that since Dec. 29, Russia has used almost 300 missiles and more than 200 Shahed drones against Ukraine.

On Saturday, shelling of the Russian border city of Belgorod killed more than two dozen people. Russia blamed Ukraine for the attack and has struck back repeatedly since then.

The Belgorod attack was one of the deadliest on Russian soil since Moscow’s full-scale invasion of Ukraine started more than 22 months ago. Russian officials said the death toll reached 26, including five children, after a new salvo of rockets Tuesday. (ap/ez)